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Vegans and "patients with diseases like Crohn's and colitis as well as people with pernicious anemia are also particularly vulnerable to deficiency," added Silverstein

Sirius red staining with polarized microscopy was conducted to evaluate the maturity of the extracellular matrix, especially secretion and production of collagen type 1, which is the major component in tendon and scarring tissue

Typical doses used in practice are in the region of 1,000 micrograms daily of cyanocobalamin, which is the standard licensed oral form in the UK

Unlike standard sterile water for research which contains no preservative and must be used immediately after opening, bacteriostatic water maintains sterility through multiple punctures, making it ideal for laboratory applications requiring frequent use or multi-application protocols